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Article

Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway

2022-09-09

Abstract excerpt

<h4>Background: </h4> The effect of platelet factor 4 (PF4) on bone marrow mesenchymal stem cells (BMMSCs) and osteoporosis remains poorly understood. Hence, this study aimed to evaluate the effects of PF4-triggered bone destruction of mice and determine the underlying mechanism. Methods Firstly, in vitro cell proliferation and cell cycle of BMMSCs were assessed by a CCK8 assay and flow cytometry, respectively. O...

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Literature Corpus work
de8c8410-93c9-5932-80df-895d146126db
DOI
10.21203/rs.3.rs-2028573/v1
Open publication

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Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathwayDOI 10.21203/rs.3.rs-2028573/v1
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