Article
Interferon λ 3 and 4 Genotyping Using High-Resolution Melt Curve Analysis Suitable for Multiple Clinical Sample Types.
The Journal of molecular diagnostics : JMD - 1 Sept 2015
Lamoury François M J, Bartlett Sofia, Jacka Brendan, Hajarizadeh Behzad, Grebely Jason, Matthews Gail V, Dore Gregory J, Applegate Tanya L
Abstract excerpt
Many people living with hepatitis C virus (HCV) infection will continue to rely on interferon-based regimens until effective strategies to minimize the cost of directly acting antivirals (DAAs) and to improve treatment access are implemented. Host single-nucleotide polymorphisms related to IFNL3 and IFNL4 are associated with spontaneous clearance of HCV, and pegylated interferon- and DAA-based treatment outcomes....
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