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Ferric Uptake Regulator Fur Control of Putative Iron Acquisition Systems in Clostridium difficile

7 Jul 2015

Abstract excerpt

UNLABELLED: Clostridium difficile is an anaerobic, Gram-positive, spore-forming opportunistic pathogen and is the most common cause of hospital-acquired infectious diarrhea. Although iron acquisition in the host is a key to survival of bacterial pathogens, high levels of intracellular iron can increase oxidative damage. Therefore, expression of iron acquisition mechanisms is tightly controlled by transcriptional...

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PMID: 26148711
DOI: 10.1128/jb.00098-15

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