Article
Iron and fur regulation in Vibrio cholerae and the role of fur in virulence.
Infection and immunity - 1 Dec 2005
Mey Alexandra R, Wyckoff Elizabeth E, Kanukurthy Vanamala, Fisher Carolyn R, Payne Shelley M
Abstract excerpt
Regulation of iron uptake and utilization is critical for bacterial growth and for prevention of iron toxicity. In many bacterial species, this regulation depends on the iron-responsive master regulator Fur. In this study we report the effects of iron and Fur on gene expression in Vibrio cholerae. We show that Fur has both positive and negative regulatory functions, and we demonstrate Fur-independent regulation...
Topics
- Bacterial Proteins
- Down-Regulation
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Iron
- Mutation
- Oligonucleotide Array Sequence Analysis
- Repressor Proteins
- Up-Regulation
- Vibrio cholerae
- Virulence