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Article

An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer.

International journal of cancer - 1 Jan 2016

Chen Changhao, Cai Qingqing, He Wang, Li Zhihua, Zhou Fangjian, Liu Zhuowei, Zhong Guangzheng, Chen Xu, Zhao Yue, Dong Wen, Huang Jian, Zheng Jianping, Lin Tianxin

Abstract excerpt

The L-plastin gene is involved in the invasion and metastasis of prostate cancer. However, the molecular mechanisms underlying L-plastin transcription are unclear. We hypothesize that the occurrence of polymorphic genetic variations in the L-plastin promoter might affect an individual's susceptibility to prostate cancer. In this study, we identified a single nucleotide polymorphism (SNP) at position -1,687 in the...

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PMID: 26148677
DOI: 10.1002/ijc.29677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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