Article
Genetic variants of the autophagy pathway as prognostic indicators for prostate cancer.
Scientific reports - 14 Sept 2015
Huang Chao-Yuan, Huang Shu-Pin, Lin Victor C, Yu Chia-Cheng, Chang Ta-Yuan, Lu Te-Ling, Chiang Hung-Chih, Bao Bo-Ying
Abstract excerpt
Autophagy is a complex process of autodigestion in conditions of cellular stress, and it might play an important role in the pathophysiology during carcinogenesis. We hypothesize that genetic variants of the autophagy pathway may influence clinical outcomes in prostate cancer patients. We genotyped 40 tagging single-nucleotide polymorphisms (SNPs) from 7 core autophagy pathway genes in 458 localized prostate...
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