Article
Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity.
Cell reports - 14 Jul 2015
Yao Fei, Kausalya Jaya P, Sia Yee Yen, Teo Audrey S M, Lee Wah Heng, Ong Alicia G M, Zhang Zhenshui, Tan Joanna H J, Li Guoliang, Bertrand Denis, Liu Xingliang, Poh Huay Mei, Guan Peiyong, Zhu Feng, Pathiraja Thushangi Nadeera, Ariyaratne Pramila N, Rao Jaideepraj, Woo Xing Yi, Cai Shaojiang, Mulawadi Fabianus H, Poh Wan Ting, Veeravalli Lavanya, Chan Chee Seng, Lim Seong Soo, Leong See Ting, Neo Say Chuan, Choi Poh Sum D, Chew Elaine G Y, Nagarajan Niranjan, Jacques Pierre-Étienne, So Jimmy B Y, Ruan Xiaoan, Yeoh Khay Guan, Tan Patrick, Sung Wing-Kin, Hunziker Walter, Ruan Yijun, Hillmer Axel M
Abstract excerpt
Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties. Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians. Rearrangements were enriched in open chromatin and shaped by chromatin structure. We identified seven rearrangement hot spots and 136 gene fusions. In three out of 100 GC cases, we found recurrent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.