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Article

RNA sequencing of esophageal adenocarcinomas identifies novel fusion transcripts, including NPC1‐MELK, arising from a complex chromosomal rearrangement

22 Jun 2017

Abstract excerpt

BACKGROUND: Studies of chromosomal rearrangements and fusion transcripts have elucidated mechanisms of tumorigenesis and led to targeted cancer therapies. This study was aimed at identifying novel fusion transcripts in esophageal adenocarcinoma (EAC). METHODS: To identify new fusion transcripts associated with EAC, targeted RNA sequencing and polymerase chain reaction (PCR) verification were performed in 40 EACs...

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PMID: 28640357
DOI: 10.1002/cncr.30837

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