Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circadian phenotyping of obese and diabetic db/db mice.

Biochimie - 1 May 2016

Grosbellet Edith, Dumont Stephanie, Schuster-Klein Carole, Guardiola-Lemaitre Beatrice, Pevet Paul, Criscuolo François, Challet Etienne

Abstract excerpt

Growing evidence links metabolic disorders to circadian alterations. Genetically obese db/db mice, lacking the long isoform of leptin receptor, are a recognized model of type 2 diabetes. In this study, we aimed at characterizing the potential circadian alterations of db/db mice in comparison to db/+ control mice. By using telemetry devices, we first reported arrhythmicity in general activity of most db/db mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Temperature
Share to Circadian Rhythm
Share to Hypothalamus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Obese

Share to Mitogen-Activated Protein Kinase 3

Share to Period Circadian Proteins

Share to Proto-Oncogene Proteins c-fos

Share to Species Specificity

Source

Identifiers

PMID: 26144489
DOI: 10.1016/j.biochi.2015.06.029

Genes

BMAL1
PER1
FOS
PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circadian phenotyping of obese and diabetic db/db mice.PMID 26144489Read ↗

Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice.Semantic proximity Read ↗

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian ClockSemantic proximity Read ↗

Cryptochrome-dependent circadian periods in the arcuate nucleus.Semantic proximity Read ↗

Cardiovascular and autonomic phenotype of db/db diabetic mice.Semantic proximity Read ↗

Obesity and metabolic syndrome in circadian Clock mutant mice.Semantic proximity Read ↗

Disruption of circadian clocks promote progression of Alzheimer's disease in diabetic miceSemantic proximity Read ↗

Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice.Semantic proximity Read ↗

Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele.Semantic proximity Read ↗

Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction.Semantic proximity Read ↗

Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice.Semantic proximity Read ↗

Restoration of circadian rhythmicity in circadian clock-deficient mice in constant light.Semantic proximity Read ↗

Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light, and dynamics of Per1 and Per2 gene expression under long and short photoperiods.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.