Article
Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice.
Physiological genomics - 13 Apr 2006
Jürgens Hella S, Schürmann Annette, Kluge Reinhart, Ortmann Sylvia, Klaus Susanne, Joost Hans-Georg, Tschöp Matthias H
Abstract excerpt
Among polygenic mouse models of obesity, the New Zealand obese (NZO) mouse exhibits the most severe phenotype, with fat depots exceeding 40% of total body weight at the age of 6 mo. Here we dissected the components of energy balance including feeding behavior, locomotor activity, energy expenditure, and thermogenesis compared with the related lean New Zealand black (NZB) and obese B6.V-Lep(ob)/J (ob/ob) strains...
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