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Article

Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2009

Goncalves Andrey C da Costa, Tank Jens, Diedrich André, Hilzendeger Aline, Plehm Ralph, Bader Michael, Luft Friedrich C, Jordan Jens, Gross Volkmar

Abstract excerpt

Leptin receptor-deficient db/db mice develop human type 2 diabetes mellitus, hypertension, and obesity with disrupted circadian blood pressure (BP) rhythm. Whether leptin is the sole mechanism mediating autonomic imbalance and hypertension is unclear. To explore this notion further, we measured BP by radiotelemetry combined with fast Fourier transformation and assessed autonomic function pharmacologically before...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19029483
DOI: 10.1161/HYPERTENSIONAHA.108.124776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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