Article
Obesity and metabolic syndrome in circadian Clock mutant mice.
Science (New York, N.Y.) - 13 May 2005
Turek Fred W, Joshu Corinne, Kohsaka Akira, Lin Emily, Ivanova Ganka, McDearmon Erin, Laposky Aaron, Losee-Olson Sue, Easton Amy, Jensen Dalan R, Eckel Robert H, Takahashi Joseph S, Bass Joseph
Abstract excerpt
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of...
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