Variation of mutant allele frequency in NRAS Q61 mutated melanomas.

Abstract excerpt

BACKGROUND: Somatic mutations of BRAF or NRAS activating the MAP kinase cell signaling pathway are present in 70% of cutaneous melanomas. The mutant allele frequency of BRAF V600E (M%BRAF) was recently shown to be highly heterogeneous in melanomas. The present study focuses on the NRAS Q61 mutant allele frequency (M%NRAS). METHODS: Retrospective quantitative analyze of 104 NRAS mutated melanomas was performed...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosome Aberrations
• Share to Chromosomes, Human, Pair 1
• Share to DNA Copy Number Variations