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Article

Overexpression of mutant HSP27 causes axonal neuropathy in mice.

Journal of biomedical science - 19 Jun 2015

Lee Jinho, Jung Sung-Chul, Joo Jaesoon, Choi Yu-Ri, Moon Hyo Won, Kwak Geon, Yeo Ha Kyung, Lee Ji-Su, Ahn Hye-Jee, Jung Namhee, Hwang Sunhee, Rheey Jingeun, Woo So-Youn, Kim Ji Yon, Hong Young Bin, Choi Byung-Ok

Abstract excerpt

BACKGROUND: Mutations in heat shock 27 kDa protein 1 (HSP27 or HSPB1) cause distal hereditary motor neuropathy (dHMN) or Charcot-Marie-Tooth disease type 2 F (CMT2F) according to unknown factors. Mutant HSP27 proteins affect axonal transport by reducing acetylated tubulin. RESULTS: We generated a transgenic mouse model overexpressing HSP27-S135F mutant protein driven by Cytomegalovirus (CMV) immediate early...

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Source

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Identifiers

PMID: 26141737
DOI: 10.1186/s12929-015-0154-y
PMCID: PMC4490621

Genes

HSPB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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