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Article

Neuropathy-Associated HSPB1 Mutant Impairs Neuronal Mechanoadaptation and Axonal Regeneration.

Cells - 3 Jul 2026

Xie Jiming, Han Ronglin, Xu Haidong, Li Zhiyu, Zhao Jingyi, Wan Ying, Pan Xianchao, Xing Juan

Abstract excerpt

The small heat shock protein HSPB1 is a ubiquitously expressed mechanoresponsive chaperone essential for cytoskeletal remodeling under mechanical load. Mutations in HSPB1, including S135F, cause Charcot-Marie-Tooth (CMT) peripheral neuropathy, yet the mechanisms underlying the selective vulnerability of peripheral nerves remain enigmatic. Here we demonstrate that substrate stiffness is a critical determinant of...

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Identifiers

PMID: 42439690
DOI: 10.3390/cells15131216
PMCID: PMC13359669

Genes

HSPB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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