Article
A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Misfolded Proteins.
Cells - 15 Sept 2022
Zhang Xuelian, Qiao Yaru, Han Ronglin, Gao Yingjie, Yang Xun, Zhang Ying, Wan Ying, Yu Wei, Pan Xianchao, Xing Juan
Abstract excerpt
Charcot-Marie-Tooth (CMT) disease is the most common inherited neurodegenerative disorder with selective degeneration of peripheral nerves. Despite advances in identifying CMT-causing genes, the underlying molecular mechanism, particularly of selective degeneration of peripheral neurons remains to be elucidated. Since peripheral neurons are sensitive to multiple stresses, we hypothesized that daily repeated...
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