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Article

Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus.

Journal of neuromuscular diseases - 27 May 2016

Bouhy Delphine, Geuens Thomas, De Winter Vicky, Almeida-Souza Leonardo, Katona Istvan, Weis Joachim, Hochepied Tino, Goossens Steven, Haigh Jody J, Janssens Sophie, Timmerman Vincent

Abstract excerpt

BACKGROUND: Charcot-Marie-Tooth (CMT) and associated neuropathies, the most common inherited diseases of the peripheral nervous system, remain so far incurable. Three existing murine models of Charcot-Marie-Tooth type 2F (CMT2F) and/or distal hereditary motor neuropathy type IIb (dHMNIIb), caused by mutations in the small heat shock protein B1 gene (HSPB1/HSP27), partially recapitulate the hallmarks of peripheral...

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Identifiers

PMID: 27854215
DOI: 10.3233/JND-150144

Genes

HSPB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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