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Article

Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation.

Journal of lipid research - 1 Mar 2004

Wang Helen H, Afdhal Nezam H, Gendler Sandra J, Wang David Q-H

Abstract excerpt

Gallbladder mucins play a critical role in the pathogenesis of cholesterol gallstones because of their ability to bind biliary lipids and accelerate cholesterol crystallization. Mucin secretion and accumulation in the gallbladder is determined by multiple mucin genes. To study whether mucin gene 1 (Muc1) influences susceptibility to cholesterol cholelithiasis, we investigated male Muc1-deficient (Muc1(-/-)) and...

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PMID: 14703511
DOI: 10.1194/jlr.M300468-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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