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Article

Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study.

EBioMedicine - 1 Apr 2015

Yoshino Takayuki, Muro Kei, Yamaguchi Kensei, Nishina Tomohiro, Denda Tadamichi, Kudo Toshihiro, Okamoto Wataru, Taniguchi Hiroya, Akagi Kiwamu, Kajiwara Takeshi, Hironaka Shuichi, Satoh Taroh

Abstract excerpt

BACKGROUND: RAS (KRAS and NRAS) testing is required to predict anti-epidermal growth factor receptor (EGFR) treatment efficacy in metastatic colorectal cancer (CRC). Although direct sequencing (DS) with manual microdissection (MMD) is widely used, a diagnostic kit providing rapid detections of RAS mutations would be clinically beneficial. We evaluated the MEBGEN(TM) RASKET KIT (RASKET KIT), a multiplex assay...

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Identifiers

PMID: 26137573
DOI: 10.1016/j.ebiom.2015.02.007
PMCID: PMC4486202

Genes

KIT
KRAS
MMD
EGFR
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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