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Article

Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015

Alhajjat Amir M, Strong Beverly S, Lee Amanda E, Turner Lucas E, Wadhwani Ram K, Ortaldo John R, Heusel Jonathan W, Shaaban Aimen F

Abstract excerpt

Little is known about how the prenatal interaction between NK cells and alloantigens shapes the developing NK cell repertoire toward tolerance or immunity. Specifically, the effect on NK cell education arising from developmental corecognition of alloantigens by activating and inhibitory receptors with shared specificity is uncharacterized. Using a murine prenatal transplantation model, we examined the manner in...

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Identifiers

PMID: 26136432
DOI: 10.4049/jimmunol.1500463
PMCID: PMC4574102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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