Confirmation of Host Genetic Determinants in the CFH Region and Susceptibility to Meningococcal Disease in a Central European Study Sample.

doi:10.1097/INF.0000000000000823

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Confirmation of Host Genetic Determinants in the CFH Region and Susceptibility to Meningococcal Disease in a Central European Study Sample.

The Pediatric infectious disease journal - 1 Oct 2015

Biebl Ariane, Muendlein Axel, Kinz Elena, Drexel Heinz, Kabesch Michael, Zenz Werner, Elling Roland, Müller Christoph, Keil Thomas, Lau Susanne, Simma Burkhard

Abstract excerpt

BACKGROUND: Invasive meningococcal disease (IMD) is a leading cause of meningitis and severe sepsis in children and adolescents. Genetic factors are important in determining the susceptibility to and outcome of IMD. Recently, a genome-wide association study from the United Kingdom showed significant associations of single-nucleotide polymorphisms within complement factor H (CFH; rs1065489) and in CFH-related...

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PMID: 26135246
DOI: 10.1097/INF.0000000000000823

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