Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.

doi:10.1038/srep35842

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Article

Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.

Scientific reports - 2 Nov 2016

Martinón-Torres Federico, Png Eileen, Khor Chiea Chuen, Davila Sonia, Wright Victoria J, Sim Kar Seng, Vega Ana, Fachal Laura, Inwald David, Nadel Simon, Carrol Enitan D, Martinón-Torres Nazareth, Alonso Sonia Marcos, Carracedo Angel, Morteruel Elvira, López-Bayón Julio, Torre Andrés Concha, Monge Cristina Calvo, de Aguilar Pilar Azcón González, Torné Elisabeth Esteban, Martínez-Padilla María Del Carmen, Martinón-Sánchez José María, Levin Michael, Hibberd Martin L, Salas Antonio

Abstract excerpt

Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a...

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PMID: 27805046
DOI: 10.1038/srep35842
PMCID: PMC5090968

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