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Article

Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients.

Scandinavian journal of infectious diseases - 1 Jan 2006

Haralambous Elene, Dolly Saoirse O, Hibberd Martin L, Litt David J, Udalova Irina A, O'dwyer Cliona, Langford Paul R, Simon Kroll J, Levin Michael

Abstract excerpt

Defence against Neisseria meningitidis involves complement-mediated bactericidal activity. Factor H (fH) down-regulates complement activation. A putatively functional single-nucleotide-polymorphism (SNP) exists within a presumed nuclear-factor-kappa-B responsive element (NF-kB) in the fH gene (C-496T). Genetic and functional investigations were carried out to determine whether C-496T has a role in meningococcal...

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Identifiers

PMID: 16938729
DOI: 10.1080/00365540600643203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients.PMID 16938729Read ↗

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