Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice

2 Jul 2015

Abstract excerpt

Telomere shortening is common in bone marrow failure syndromes such as dyskeratosis congenita (DC), aplastic anemia (AA) and myelodysplastic syndromes (MDS). However, improved knowledge of the lineage-specific consequences of telomere erosion and restoration of telomere length in hematopoietic progenitors is required to advance therapeutic approaches. We have employed a reversible murine model of telomerase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26133370
DOI: 10.1371/journal.pone.0131722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout MicePMID 26133370Read ↗

Telomere maintenance and human bone marrow failure.Semantic proximity Read ↗

Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.Semantic proximity Read ↗

Understanding telomere diseases through analysis of patient-derived iPS cells.Semantic proximity Read ↗

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia.Semantic proximity Read ↗

Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.Semantic proximity Read ↗

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germlineSemantic proximity Read ↗

Short telomeres resulting from heritable mutations in the telomerase reverse transcriptase gene predispose for a variety of malignancies.Semantic proximity Read ↗

Role of Telomerase in Hematopoietic Stem CellsSemantic proximity Read ↗

Heterozygous telomerase deficiency in mouse and man: when less is definitely not more.Semantic proximity Read ↗

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Semantic proximity Read ↗

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.