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Article

Telomere maintenance and human bone marrow failure.

Blood - 1 May 2008

Calado Rodrigo T, Young Neal S

Abstract excerpt

Acquired and congenital aplastic anemias recently have been linked molecularly and pathophysiologically by abnormal telomere maintenance. Telomeres are repeated nucleotide sequences that cap the ends of chromosomes and protect them from damage. Telomeres are eroded with cell division, but in hematopoietic stem cells, maintenance of their length is mediated by telomerase. Accelerated telomere shortening is...

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Source

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Identifiers

PMID: 18239083
DOI: 10.1182/blood-2007-08-019729
PMCID: PMC2343587

Genes

TERT
DKC1
NOP10
TINF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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