Article
Telomere maintenance and human bone marrow failure.
Blood - 1 May 2008
Calado Rodrigo T, Young Neal S
Abstract excerpt
Acquired and congenital aplastic anemias recently have been linked molecularly and pathophysiologically by abnormal telomere maintenance. Telomeres are repeated nucleotide sequences that cap the ends of chromosomes and protect them from damage. Telomeres are eroded with cell division, but in hematopoietic stem cells, maintenance of their length is mediated by telomerase. Accelerated telomere shortening is...
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