Article

Decoding RNA Triple Helices: Identification from Sequence and Secondary Structure

2025-10-03

Abstract excerpt

The discovery of long non-coding RNAs has revealed additional layers of gene-expression control. Specific interactions of lncRNAs with DNA, RNAs, and RNA-binding proteins enable regulation in both cytoplasmic and nuclear compartments; for example, a conserved triple-helix motif is essential for MALAT1 stability and oncogenic activity. Here we present a secondary-structure–based framework to annotate and detect RNA...

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Literature Corpus work: 5c2daea7-0e68-5a7c-9f31-32080777e263
DOI: 10.1101/2025.10.01.679706

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