Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.

doi:10.1172/JCI45235

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Article

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.

The Journal of clinical investigation - 1 Jun 2011

Rotger Margalida, Dalmau Judith, Rauch Andri, McLaren Paul, Bosinger Steven E, Martinez Raquel, Sandler Netanya G, Roque Annelys, Liebner Julia, Battegay Manuel, Bernasconi Enos, Descombes Patrick, Erkizia Itziar, Fellay Jacques, Hirschel Bernard, Miró Jose M, Palou Eduard, Hoffmann Matthias, Massanella Marta, Blanco Julià, Woods Matthew, Günthard Huldrych F, de Bakker Paul, Douek Daniel C, Silvestri Guido, Martinez-Picado Javier, Telenti Amalio

Abstract excerpt

High levels of HIV-1 replication during the chronic phase of infection usually correlate with rapid progression to severe immunodeficiency. However, a minority of highly viremic individuals remains asymptomatic and maintains high CD4⁺ T cell counts. This tolerant profile is poorly understood and reminiscent of the widely studied nonprogressive disease model of SIV infection in natural hosts. Here, we identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21555857
DOI: 10.1172/JCI45235
PMCID: PMC3104754

Genes

CASP1
LAG3
SOCS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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