Article
Intrahepatic Cholestasis of Pregnancy (ICP) in U.S. Latinas and Chileans: Clinical features, Ancestry Analysis, and Admixture Mapping.
PloS one - 1 Jan 2015
Bull Laura N, Hu Donglei, Shah Sohela, Temple Luisa, Silva Karla, Huntsman Scott, Melgar Jennifer, Geiser Mary T, Sanford Ukina, Ortiz Juan A, Lee Richard H, Kusanovic Juan P, Ziv Elad, Vargas Juan E
Abstract excerpt
In the Americas, women with Indigenous American ancestry are at increased risk of intrahepatic cholestasis of pregnancy (ICP), relative to women of other ethnicities. We hypothesized that ancestry-related genetic factors contribute to this increased risk. We collected clinical and laboratory data, and performed biochemical assays on samples from U.S. Latinas and Chilean women, with and without ICP. The study...
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