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Article

Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis.

The Journal of biological chemistry - 14 Aug 2015

Maguire Sarah E, Rhoades Seth, Chen Wen-Feng, Sengupta Arjun, Yue Zhifeng, Lim Jason C, Mitchell Claire H, Weljie Aalim M, Sehgal Amita

Abstract excerpt

Breakdown of the major sleep-promoting neurotransmitter, γ-aminobutyric acid (GABA), in the GABA shunt generates catabolites that may enter the tricarboxylic acid cycle, but it is unknown whether catabolic by-products of the GABA shunt actually support metabolic homeostasis. In Drosophila, the loss of the specific enzyme that degrades GABA, GABA transaminase (GABAT), increases sleep, and we show here that it also...

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Identifiers

PMID: 26124278
DOI: 10.1074/jbc.M114.602276
PMCID: PMC4536446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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