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Article

Maternal heme oxygenase 1 regulates placental vasculature development via angiogenic factors in mice.

Biology of reproduction - 1 Nov 2011

Zhao Hui, Azuma Junya, Kalish Flora, Wong Ronald J, Stevenson David K

Abstract excerpt

The placental vasculature is critical for nutrient, gas, and waste exchange between the maternal and fetal systems. Its development depends on the proper expression and interaction of angiogenesis and associated growth factors. Heme oxygenase (HMOX), the enzyme for heme degradation, plays a role in angiogenesis and is highly expressed in the placenta. To evaluate the role of maternal HMOX1, the inducible HMOX...

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Identifiers

PMID: 21778140
DOI: 10.1095/biolreprod.111.093039
PMCID: PMC3197918

Genes

HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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