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Article

Curing a large endogenous plasmid by single substitution of a partitioning gene.

Plasmid - 1 Nov 2015

Song Ningning, Xu Jie, Li Zhaoli, Hernalsteens Jean-Pierre

Abstract excerpt

To investigate whether plasmid-free cells of pathogenic Escherichia coli can be isolated by disrupting a single gene in an endogenous plasmid without further treatment, the effect of the disruption of partitioning genes on the inheritance of the endogenous plasmid pUTI89 of the uropathogenic E. coli strain UTI89 was studied. We found that mutation of parB, which encodes a type Ib partitioning protein, could cause...

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Identifiers

PMID: 26123974
DOI: 10.1016/j.plasmid.2015.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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