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Article

The Impact of the Eda Pathway on Tooth Root Development.

Journal of dental research - 1 Oct 2017

Fons Romero J M, Star H, Lav R, Watkins S, Harrison M, Hovorakova M, Headon D, Tucker A S

Abstract excerpt

The Eda pathway ( Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig's epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or...

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Source

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Identifiers

PMID: 28813629
DOI: 10.1177/0022034517725692
PMCID: PMC5613883

Genes

EDA

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