Article
Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry.
Pharmacogenomics - 1 Jan 2015
Alfirevic Ana, Durocher Jill, Elati Anisa, León Wilfrido, Dickens David, Rädisch Steffen, Box Helen, Siccardi Marco, Curley Paul, Xinarianos George, Ardeshana Arjun, Owen Andrew, Zhang J Eunice, Pirmohamed Munir, Alfirevic Zarko, Weeks Andrew, Winikoff Beverly
Abstract excerpt
AIM: Misoprostol, a prostaglandin analogue used for the treatment of postpartum hemorrhage and termination of pregnancy, can cause high fevers. Genetic susceptibility may play a role in misoprostol-induced fever. SUBJECTS & METHODS: Body temperature of women treated with misoprostol for termination of pregnancy in the UK (n = 107) and for postpartum hemorrhage in Ecuador (n = 50) was measured. Genotyping for 33...
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