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Article

Interleukin-1 receptor antagonist, mode of analgesia and risk of Caesarean delivery after onset of labour: a Mendelian randomisation analysis.

British journal of anaesthesia - 1 Jan 2022

Ackland Gareth L, Van Duijvenboden Stefan, Abbott Tom E F, Gutierrez Del Arroyo Ana, Wilson Matthew J, David Anna L

Abstract excerpt

BACKGROUND: Lower circulating levels of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) are associated with intrapartum inflammation and epidural analgesia-related maternal fever, both of which increase the rate of obstetric interventions. We hypothesised that genetic variants determining IL-1ra levels would be associated with Caesarean delivery rates after the onset of labour. METHODS:...

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Identifiers

PMID: 34802694
DOI: 10.1016/j.bja.2021.09.039
PMCID: PMC8787778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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