Article
Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms.
The pharmacogenomics journal - 1 Jun 2016
Mas S, Gassó P, Boloc D, Rodriguez N, Mármol F, Sánchez J, Bernardo M, Lafuente A
Abstract excerpt
To identify potential candidate genes for future pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we used gene expression arrays to analyze changes induced by risperidone in mice strains with different susceptibility to EPS. We proposed a systems biology analytical approach that combined the identification of gene co-expression modules related to AP treatment, the construction...
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