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Article

MTOR Pathway-Based Discovery of Genetic Susceptibility to L-DOPA-Induced Dyskinesia in Parkinson's Disease Patients.

Molecular neurobiology - 1 Mar 2019

Martín-Flores Núria, Fernández-Santiago Rubén, Antonelli Francesa, Cerquera Catalina, Moreno Verónica, Martí Maria Josep, Ezquerra Mario, Malagelada Cristina

Abstract excerpt

Dyskinesia induced by L-DOPA administration (LID) is one of the most invalidating adverse effects of the gold standard treatment restoring dopamine transmission in Parkinson's disease (PD). However, LID manifestation in parkinsonian patients is variable and heterogeneous. Here, we performed a candidate genetic pathway analysis of the mTOR signaling cascade to elucidate a potential genetic contribution to LID...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29992529
DOI: 10.1007/s12035-018-1219-1

Genes

HRAS
FCHSD1
MTOR
PRKCA
PRKN
RICTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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