Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetic predictor of extrapyramidal symptoms induced by antipsychotics: multilocus interaction in the mTOR pathway.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2015

Mas S, Gassó P, Ritter M A, Malagelada C, Bernardo M, Lafuente A

Abstract excerpt

Antipsychotic (AP) treatment-emergent extrapyramidal symptoms (EPS) are acute adverse reactions of APs. The aim of the present study is to analyze gene-gene interactions in nine genes related to the mTOR pathway, in order to develop genetic predictors of the appearance of EPS. 243 subjects (78 presenting EPS: 165 not) from three cohorts participated in the present study: Cohort 1, patients treated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Basal Ganglia Diseases

Share to Pharmacogenetics

Share to Proto-Oncogene Proteins c-akt

Share to Psychiatric Status Rating Scales

Share to Risperidone

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 25499605
DOI: 10.1016/j.euroneuro.2014.11.011

Genes

AKT1
DDIT4
FCHSD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetic predictor of extrapyramidal symptoms induced by antipsychotics: multilocus interaction in the mTOR pathway.PMID 25499605Read ↗

Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipsychoticsSemantic proximity Read ↗

MTOR Pathway-Based Discovery of Genetic Susceptibility to L-DOPA-Induced Dyskinesia in Parkinson's Disease Patients.Semantic proximity Read ↗

SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's DiseaseSemantic proximity Read ↗

Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms.Semantic proximity Read ↗

Pharmacogenetic study of antipsychotic induced acute extrapyramidal symptoms in a first episode psychosis cohort: role of dopamine, serotonin and glutamate candidate genes.Semantic proximity Read ↗

Genetics of Common Antipsychotic-Induced Adverse EffectsSemantic proximity Read ↗

Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms.Semantic proximity Read ↗

Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic PatientsSemantic proximity Read ↗

A genetic dissection of antipsychotic induced movement disorders.Semantic proximity Read ↗

Integrative Multiomics Analysis Identifies DKK3 as a Germline Susceptibility-Related Regulator of Risperidone Response and Metabolic Risk in Schizophrenia.Semantic proximity Read ↗

Pharmacogenomic and inflammatory determinants of antipsychotic-induced extrapyramidal toxicity in Egyptian patients with schizophrenia.Semantic proximity Read ↗

Identification of novel proteins associated with movement-related adverse antipsychotic effects by integrating GWAS data and human brain proteomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.