Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sortilin regulates sorting and secretion of Sonic hedgehog.

Journal of cell science - 15 Oct 2016

Campbell Charles, Beug Shawn, Nickerson Philip E B, Peng Jimmy, Mazerolle Chantal, Bassett Erin A, Ringuette Randy, Jama Fadumo A, Morales Carlos, Christ Annabel, Wallace Valerie A

Abstract excerpt

Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth. The Shh full-length protein undergoes autocleavage in the endoplasmic reticulum to generate the biologically active N-terminal fragment (ShhN), which is destined for secretion. We identified sortilin (Sort1), a member of the VPS10P-domain receptor family, as a new Shh trafficking receptor. We demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Golgi Apparatus

Share to Hedgehog Proteins

Share to Optic Nerve

Share to PC12 Cells

Share to Retinal Ganglion Cells

Share to Secretory Pathway

Source

Identifiers

PMID: 27632999
DOI: 10.1242/jcs.183541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sortilin regulates sorting and secretion of Sonic hedgehog.PMID 27632999Read ↗

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Semantic proximity Read ↗

MORPHOGENIC VERSUS MITOGENIC ROLES OF SHH ARE SEGREGATED ON DISTINCT EXOSOMES REGULATED BY CELLULAR RAB7 LEVELSSemantic proximity Read ↗

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.Semantic proximity Read ↗

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.Semantic proximity Read ↗

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.Semantic proximity Read ↗

The Gos28 SNARE protein mediates intra-Golgi transport of rhodopsin and is required for photoreceptor survival.Semantic proximity Read ↗

Sonic hedgehog regulates its own receptor on postcrossing commissural axons in a glypican1-dependent manner.Semantic proximity Read ↗

GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.Semantic proximity Read ↗

ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis.Semantic proximity Read ↗

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency.Semantic proximity Read ↗

Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm.Semantic proximity Read ↗

Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.