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Article

TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice

13 Jan 2017

Abstract excerpt

Loss-of-function mutations in the X-linked immunoglobulin superfamily, member 1 (IGSF1) gene cause central hypothyroidism. IGSF1 is a transmembrane glycoprotein of unknown function expressed in thyrotropin (TSH)-producing thyrotrope cells of the anterior pituitary gland. The protein is cotranslationally cleaved, with only its C-terminal domain (CTD) being trafficked to the plasma membrane. Most intragenic IGSF1...

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PMID: 28324000
DOI: 10.1210/en.2016-1788

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