Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the Thyroid Gland in Expression of the Thyroid Phenotype of Sbp2-Deficient Mice.

Endocrinology - 1 May 2020

Fujisawa Haruki, Korwutthikulrangsri Manassawee, Fu Jiao, Liao Xiao-Hui, Dumitrescu Alexandra M

Abstract excerpt

Selenocysteine insertion sequence-binding protein 2, SBP2 (SECISBP2), is required for selenoprotein synthesis. Partial SBP2 deficiency syndrome manifests characteristic thyroid function tests. The Sbp2 deficiency mouse model, Sbp2 inducible conditional knockout (iCKO), replicates this thyroid phenotype and was used for pathophysiologic investigations. As selenoproteins have an antioxidative role in thyroid gland...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA-Binding Proteins
Share to Selenoproteins
Share to Thyroid Function Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Thyroid Gland

Share to Thyroid Hormones

Share to Thyrotropin

Share to Thyroxine

Share to Triiodothyronine

Source

Open in PubMed Open full text

Identifiers

PMID: 31826256
DOI: 10.1210/endocr/bqz032
PMCID: PMC7144917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the Thyroid Gland in Expression of the Thyroid Phenotype of Sbp2-Deficient Mice.PMID 31826256Read ↗

Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 DeficiencySemantic proximity Read ↗

Inherited defects of thyroid hormone metabolism.Semantic proximity Read ↗

[Disorders in thyroid hormone metabolism].Semantic proximity Read ↗

Novel biological and clinical aspects of thyroid hormone metabolism.Semantic proximity Read ↗

The syndrome of inherited partial SBP2 deficiency in humans.Semantic proximity Read ↗

Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous SBP2 (SECISBP2) Mutations.Semantic proximity Read ↗

Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2.Semantic proximity Read ↗

Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations.Semantic proximity Read ↗

Inherited Disorders of Thyroid Hormone Metabolism Defect Caused by the Dysregulation of Selenoprotein Expression.Semantic proximity Read ↗

Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X).Semantic proximity Read ↗

Selenoprotein-related disease in a young girl caused by nonsense mutations in the SBP2 gene.Semantic proximity Read ↗

A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish BoySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.