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Article

Whole-genome sequencing of recurrent neuroblastoma reveals somatic mutations that affect key players in cancer progression and telomere maintenance.

Scientific reports - 31 Dec 2020

Fransson Susanne, Martinez-Monleon Angela, Johansson Mathias, Sjöberg Rose-Marie, Björklund Caroline, Ljungman Gustaf, Ek Torben, Kogner Per, Martinsson Tommy

Abstract excerpt

Neuroblastoma is the most common and deadly childhood tumor. Relapsed or refractory neuroblastoma has a very poor prognosis despite recent treatment advances. To investigate genomic alterations associated with relapse and therapy resistance, whole-genome sequencing was performed on diagnostic and relapsed lesions together with constitutional DNA from seven children. Sequencing of relapsed tumors indicates somatic...

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Source

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Identifiers

PMID: 33384420
DOI: 10.1038/s41598-020-78370-7
PMCID: PMC7775426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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