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Article

Pathway analysis by adaptive combination of P-values.

Genetic epidemiology - 1 Dec 2009

Yu Kai, Li Qizhai, Bergen Andrew W, Pfeiffer Ruth M, Rosenberg Philip S, Caporaso Neil, Kraft Peter, Chatterjee Nilanjan

Abstract excerpt

It is increasingly recognized that pathway analyses-a joint test of association between the outcome and a group of single nucleotide polymorphisms (SNPs) within a biological pathway-could potentially complement single-SNP analysis and provide additional insights for the genetic architecture of complex diseases. Building upon existing P-value combining methods, we propose a class of highly flexible pathway...

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Identifiers

PMID: 19333968
DOI: 10.1002/gepi.20422
PMCID: PMC2790032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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