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Article

Oxidative Stress in Caenorhabditis elegans: Protective Effects of Spartin.

PloS one - 1 Jan 2015

Truong Timothy, Karlinski Zachary A, O'Hara Christopher, Cabe Maleen, Kim Hongkyun, Bakowska Joanna C

Abstract excerpt

Troyer syndrome is caused by a mutation in the SPG20 gene, which results in complete loss of expression of the protein spartin. We generated a genetic model of Troyer syndrome in worms to explore the locomotor consequences of a null mutation of the Caenorhabditis elegans SPG20 orthologue, F57B10.9, also known as spg-20. Spg-20 mutants showed decreased length, crawling speed, and thrashing frequency, and had a...

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Identifiers

PMID: 26114733
DOI: 10.1371/journal.pone.0130455
PMCID: PMC4482654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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