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fln-2 isoform-specifically regulates Caenorhabditis elegans health span by affecting pharyngeal function.

Scientific reports - 11 Feb 2026

Chang Ya-Hong, Chi Ai-Qiu, Ren Yu-Chen, Mu Xue-Pan, Tao Bei-Bei, Shao Zhiyong, Zhu Yi-Chun

Abstract excerpt

Aging is regulated by both genetic and environmental factors, and Caenorhabditis elegans is a key model due to its conserved longevity pathways. The fln-2 gene, encoding an ortholog of human filamin A (FLNa) with up to 27 isoforms, is known to modulate pharyngeal infection and lifespan in C. elegans. Still, its isoform-specific roles and mechanisms have not been fully elucidated. Here, we demonstrate that...

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PMID: 41667770
DOI: 10.1038/s41598-026-39461-z
PMCID: PMC12966323

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