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Article

Preparation by alkaline treatment and detailed characterisation of empty hepatitis B virus core particles for vaccine and gene therapy applications.

Scientific reports - 26 Jun 2015

Strods Arnis, Ose Velta, Bogans Janis, Cielens Indulis, Kalnins Gints, Radovica Ilze, Kazaks Andris, Pumpens Paul, Renhofa Regina

Abstract excerpt

Hepatitis B virus (HBV) core (HBc) virus-like particles (VLPs) are one of the most powerful protein engineering tools utilised to expose immunological epitopes and/or cell-targeting signals and for the packaging of genetic material and immune stimulatory sequences. Although HBc VLPs and their numerous derivatives are produced in highly efficient bacterial and yeast expression systems, the existing purification...

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Identifiers

PMID: 26113394
DOI: 10.1038/srep11639
PMCID: PMC4650659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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