Article
Metabolic memory in diabetic foot syndrome (DFS): MICRO-RNAS, single nucleotide polymorphisms (SNPs) frequency and their relationship with indices of endothelial function and adipo-inflammatory dysfunction.
Cardiovascular diabetology - 26 Jun 2023
Del Cuore Alessandro, Pipitone Rosaria Maria, Casuccio Alessandra, Mazzola Marco Maria, Puleo Maria Grazia, Pacinella Gaetano, Riolo Renata, Maida Carlo, Di Chiara Tiziana, Di Raimondo Domenico, Zito Rossella, Lupo Giulia, Agnello Luisa, Di Maria Gabriele, Ciaccio Marcello, Grimaudo Stefania, Tuttolomondo Antonino
Abstract excerpt
BACKGROUND: Diabetic foot is a significant cause of morbidity in diabetic patients, with a rate that is approximately twice that of patients without foot ulcers. "Metabolic memory" represents the epigenetic changes induced by chronic hyperglycaemia, despite the correction of the glucose levels themselves. These epigenetic modifications appear to perpetuate the damage caused by persistently elevated glucose levels...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.