Article
Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.
PLoS neglected tropical diseases - 1 Jan 2015
Beale Mathew A, Sabiiti Wilber, Robertson Emma J, Fuentes-Cabrejo Karen M, O'Hanlon Simon J, Jarvis Joseph N, Loyse Angela, Meintjes Graeme, Harrison Thomas S, May Robin C, Fisher Matthew C, Bicanic Tihana
Abstract excerpt
Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet little is known about the genetic markers underlying Cryptococcal virulence and patient outcome. We studied a cohort of 230 Cryptococcus neoformans (Cn) isolates from HIV-positive South African clinical trial patients with detailed clinical follow-up using multi-locus sequence typing and in vitro phenotypic virulence...
Topics
- Africa, Southern
- Cryptococcus neoformans
- Gene Frequency
- Genetic Variation
- Genotype
- Humans
- Meningitis, Cryptococcal
- Models, Genetic
- Phenotype
- Phylogeny