Article
Cryptococcal genotype influences immunologic response and human clinical outcome after meningitis.
mBio - 1 Jan 2012
Wiesner Darin L, Moskalenko Oleksandr, Corcoran Jennifer M, McDonald Tami, Rolfes Melissa A, Meya David B, Kajumbula Henry, Kambugu Andrew, Bohjanen Paul R, Knight Joseph F, Boulware David R, Nielsen Kirsten
Abstract excerpt
UNLABELLED: In sub-Saharan Africa, cryptococcal meningitis (CM) continues to be a predominant cause of AIDS-related mortality. Understanding virulence and improving clinical treatments remain important. To characterize the role of the fungal strain genotype in clinical disease, we analyzed 140 Cryptococcus isolates from 111 Ugandans with AIDS and CM. Isolates consisted of 107 nonredundant Cryptococcus neoformans...
Topics
- Acquired Immunodeficiency Syndrome
- Adult
- Cluster Analysis
- Cryptococcus neoformans
- DNA, Fungal
- Female
- Genotype
- Humans
- Male
- Meningitis, Cryptococcal