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Article

ABC transporters and the proteasome complex are implicated in susceptibility to Stevens-Johnson syndrome and toxic epidermal necrolysis across multiple drugs.

PloS one - 1 Jan 2015

Nicoletti Paola, Bansal Mukesh, Lefebvre Celine, Guarnieri Paolo, Shen Yufeng, Pe'er Itsik, Califano Andrea, Floratos Aris

Abstract excerpt

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) represent rare but serious adverse drug reactions (ADRs). Both are characterized by distinctive blistering lesions and significant mortality rates. While there is evidence for strong drug-specific genetic predisposition related to HLA alleles, recent genome wide association studies (GWAS) on European and Asian populations have failed to identify...

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Identifiers

PMID: 26110827
DOI: 10.1371/journal.pone.0131038
PMCID: PMC4482486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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