Article
Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.
Clinical pharmacology and therapeutics - 1 Mar 2018
Manolio Teri A, Hutter Carolyn M, Avigan Mark, Cibotti Ricardo, Davis Robert L, Denny Joshua C, Grenade Lois La, Wheatley Lisa M, Carrington Mary N, Chantratita Wasun, Chung Wen-Hung, Dalton Andrea D, Hung Shuen-Iu, Lee Ming Ta Michael, Leeder J Steven, Lertora Juan J L, Mahasirimongkol Surakameth, McLeod Howard L, Mockenhaupt Maja, Pacanowski Michael, Phillips Elizabeth J, Pinheiro Simone, Pirmohamed Munir, Sung Cynthia, Suwankesawong Wimon, Trepanier Lauren, Tumminia Santa J, Veenstra David, Yuliwulandari Rika, Shear Neil H
Abstract excerpt
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much...
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